Jason Reitman and writer Diablo Cody first collaborated on the filming of her debut script Juno in 2007. Four years later, they made Young Adult with Charlize Theron, and now all three reunite for Tully, the latest tip of the cap to motherhood and self-care. Simpatico is the word that comes to mind here with the perfect lineup of writer, director and actress. The biggest question is how to label it. Some will call it a comedy, while others will proclaim it a serious drama. As with much of life, there is a bit of laughter, a touch of drama, and a dash of most every emotion.

Ms. Theron stars as Marlo, a mother of three. There is 8-year old daughter Sarah (Lia Frankland), 6-year old son Jonah (Asher Miles Fallica), who lands on the autistic spectrum, and now an unplanned newborn that threatens to rock a family already barely getting through each day. Sarah is a lovely sister and daughter, but the typical tween-age insecurities are magnified by her getting overlooked due to her more needy siblings. Jonah gets booted from kindergarten by a principal who labels him “quirky,” an awkward description people use when they are trying to be polite (even though it’s exactly the opposite).

Ron Livingston plays Marlo’s husband Drew, a traveling businessman who, though a nice guy and loving father, is clueless to the stresses of running the homestead. Also in the mix is Craig (Mark Duplass), Marlo’s brother who is equal parts wealthy and smug. When Craig offers the gift of a night-nanny to Marlo, she is tempted, but her pride gets in the way as she compares herself to the ‘cupcake’ super moms who always seem to have their act together. Ultimately, the relentless pressure and sleep deprivation bring the young night-nanny Tully (Mackenzie Davis) into the home. She and Marlo hit it off immediately leading Marlo (and us) to question if Tully is too good to be true.

As Tully entrenches herself, it becomes clear that her value is to Marlo more than the baby. The two ladies become friends, and Marlo confesses her fears and insecurities as Tully acts as a life coach encouraging her through some tough moments. Despite the surreal feel to these interactions, Diablo Cody’s dialogue crackles with cynicism and realism. The quips we’ve come to expect from her writing are delivered by her best developed character to date. There is a depth to Marlo, and her exchanges with Tully take us places a teenage Juno couldn’t possibly.

Charlize Theron proves again that she is truly an elite actress when she commits to a role. Her 50 lb weight game adds the necessary realism, but it’s her emotional teetering that is most impressive. She is like a supermodel who also plays rugby – a rare blend of beauty, talent and skill. Mackenzie Davis is a revelation. She holds her own in every scene and it’s quite interesting to see her free-spirited modern day Mary Poppins with tats.

If a previous movie has dealt with the challenge and stress of motherhood with this level of depth and realism, it doesn’t come to mind. The movie kind of creeps up on you with a message regarding the importance of dealing with lost youth, while also never losing sight of yourself as an individual…all with incisive humor and pulling no punches on being an overwhelmed mom. Just don’t call it quirky.